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US Panel Backs Merck COVID-19 Pill 12/01 06:12
A panel of U.S. health advisers on Tuesday narrowly backed a closely watched
COVID-19 pill from Merck, setting the stage for a likely authorization of the
first drug that Americans could take at home to treat the coronavirus.
WASHINGTON (AP) -- A panel of U.S. health advisers on Tuesday narrowly
backed a closely watched COVID-19 pill from Merck, setting the stage for a
likely authorization of the first drug that Americans could take at home to
treat the coronavirus.
The Food and Drug Administration panel voted 13-10 that the antiviral drug's
benefits outweigh its risks, including potential birth defects if used during
pregnancy.
"I see this as an incredibly difficult decision with many more questions
than answers," said panel chair Dr. Lindsey Baden of Harvard Medical School,
who voted in favor of the drug. He said FDA would have to carefully tailor the
drug's use for patients who stand to benefit most.
The recommendation came after hours of debate about the drug's modest
benefits and potential safety issues. Most experts backing the treatment
stressed that it should not be used by anyone who is pregnant and called on FDA
to recommend extra precautions before the drug is prescribed, such as pregnancy
tests for women of child-bearing age.
The vote specifically backed the drug for adults with mild-to-moderate
COVID-19 who face the greatest risks, including older people and those with
conditions like obesity and asthma. Most experts also said the drug shouldn't
be used in vaccinated people, who weren't part of Merck's research and haven't
been shown to benefit.
The FDA isn't bound by the panel's recommendation and is expected to make
its own decision before year's end. The antiviral is already authorized in the
U.K.
The drug, molnupiravir, could provide a much-needed weapon against the virus
as colder weather pushes case counts higher and U.S. officials brace for the
arrival of the new omicron variant.
Merck hasn't specifically tested its drug against the new variant but said
it should have some potency based on its effectiveness against other strains of
coronavirus.
That uncertainty frustrated many panelists as they grappled with whether to
back the treatment for millions of Americans.
"With no data saying it works with new variants, I really think we need to
be careful about saying that this is the way to go," said Dr. David Hardy of
Charles Drew University School of Medicine and Science, who ultimately voted to
back the drug.
On Friday, Merck released updated data that paint a less compelling picture
of the drug's effectiveness than just a few weeks earlier.
Merck said final study results showed molnupiravir reduced hospitalization
and death by 30% among adults infected with the coronavirus, when compared with
adults taking a placebo. That effect was significantly less than the 50%
reduction it first announced based on incomplete results.
For many panelists, the modest effect wasn't enough to outweigh the drug's
potential toxicity to human fetuses.
"Given the large potential population affected, the risk of widespread
effects on potential birth defects has not been adequately studied," said Dr.
Sankar Swaminathan of the University of Utah School of Medicine, who voted
against the drug.
FDA scientists told the panelists earlier Tuesday that company studies in
rats showed the drug caused birth defects when given at very high doses. FDA
staffers concluded the data "suggest that molnupiravir may cause fetal harm
when administered to pregnant individuals."
The agency is weighing a blanket restriction against any use in pregnant
women or allowing doctors to use the drug in rare cases. Some panelists said
that option should be left open for pregnant mothers who have high-risk
COVID-19 and may have few other treatment options.
Dr. Janet Cragan, who backed the drug, said that even with tight
restrictions some pregnant women would inevitably take the antiviral.
"I don't think you can ethically tell a woman with COVID-19 that she can't
have the drug if she's decided that's what she needs," said Cragan, a panel
member and staffer with the Centers for Disease Control and Prevention. "I
think the final decision has to come down to the individual woman and her
provider."
Merck's drug uses a novel approach to fight COVID-19: It inserts tiny errors
into the coronavirus' genetic code to stop it from reproducing. That genetic
effect has raised concerns that the drug could spur more virulent strains of
the virus. FDA regulators said Tuesday that risk is theoretical but many
panelists said it should be carefully tracked in follow-up studies.
Antiviral pills have long been seen as a key advance beyond currently used
antibody drugs, which must be injected or infused by health professionals. But
given the shortcomings of Merck's data, several experts said they would
prioritize patients to receive the older drugs.
While Merck and its partner Ridgeback Biotherapeutics were the first to
submit their COVID-19 pill to the FDA, rival drugmaker Pfizer is close behind
with its own pill under review.
Pfizer's drug is part of a decades-old family of antiviral pills known as
protease inhibitors, a standard treatment for HIV and hepatitis C. They work
differently than Merck's pill and haven't been linked to the kind of mutation
concerns raised with Merck's drug.
Pfizer said this week that its drug shouldn't be affected by the omicron
variant's mutations.
Both drugs require patients to take multiple pills, twice a day for five
days.
The U.S. government has agreed to purchase 10 million treatment courses of
Pfizer's drug, if it's authorized. That's more than three times the
government's purchase agreement with Merck for 3.1 million courses of
molnupiravir.
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